Xavier Pivot

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

Antibody–drug conjugates (ADCs) are often described as simple carriers that shuttle cytotoxic payloads to tumors. However, many backbones, exemplified by trastuzumab, are potent biologics whose pharmacology is eroded by conjugation. In this Perspective, we introduce the concept of an antibody exposure deficit. This rep...