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Author

Xi Chen

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Sep 2026

Abstract A007: Spatial Single-Cell Multi-Omics Identifies Niche Modulated MIC-to-MCC Plasticity Underlying Pancreatic Cancer Hepatic Metastasis

Pancreatic ductal adenocarcinoma (PDAC) confers dismal clinical outcomes largely owing to its robust metastatic propensity, among which liver metastasis accounts for the deadliest metastatic phenotype. The core malignant cell populations governing the onset and outgrowth of PDAC hepatic metastasis, as well as their s...

Xi Chen · 0 citations
Jul 2026

Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in glioma.

This work integrated single-cell profiling and spatial transcriptomics of glioma-associated microglia in the GL261 model to identify distinct microglial states that aligned with tumor architecture and highlighted microglial state transitions as a stage-specific layer of immune regulation in glioma that shapes T cell fa...

Jia-Wen Qian, Chen Wang, Yi Zhang et al. · 0 citations
Jul 2026

Spatiotemporal multiomics uncover tumor ecosystem dynamics during metastatic colonization.

A residual population of quiescent Phgdhhigh DTCs that survived initial innate immune clearance and became transiently enriched in micrometastases are identified, providing insights into the development of micrometastasis-targeting regimens.

Yun-Fan Sun, Y. Zhong, Shang Liu et al. · 0 citations

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