This review systematically dissects the cellular architecture, maturation dynamics, and spatial heterogeneity of TLS in primary and metastatic CRC, clarifying how these attributes dictate clinical outcomes and treatment responsiveness.
Zhi-Liang Li, Wenqing Jia, Zichao Guo et al.· Cancer Drug Resistance· 0 citations
A gene signature associated with epithelial-mesenchymal transition that integrates TME dynamics, prognosis prediction, and drug resistance assessment in CRC holds significant value for predicting clinical prognosis, immunotherapy responsiveness, and chemotherapy sensitivity in CRC.
Xiaonan Shen, Hao Zhong, Wenqing Jia et al.· Cancer Drug Resistance· 0 citations
At single-cell resolution, ZBTB21 emerges as a metabolic regulator that strengthens serine biosynthesis and redox homeostasis and provides mechanistic insights and potential strategies for metabolic-targeted therapies in CRC.
Yimei Jiang, Hai-Yan Huang, Haoran Feng et al.· Cancer Immunology and Immuno...· 0 citations
It is suggested that Hashimoto’s thyroiditis reshapes both epithelial transcriptional states and the intratumoral microbial environment, potentially contributing to a less aggressive tumor phenotype.
Yu Che, W. Kou, Lianghui Xu et al.· iScience· 0 citations
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