Xi-Fei Yang

UA-30 mitigates systemic aging and motor decline by inhibiting RalA signaling in naturally aged mice.

UA-30 ameliorates motor deficits through RalA-mediated mitophagy in ALS mice

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, skeletal muscle atrophy, paralysis, and eventually death. Mitochondrial dysfunction plays a pivotal role in ALS pathogenesis, although the precise pathogenic mechanisms remain elusive, and effective therap...

Targeting C/EBPβ/ Calbindin 1 pathway bolsters the neural resilience to tau pathology and improves tau-impaired episodic memory.

Endothelial C/EBPβ/AEP pathway drives vascular deterioration and systemic aging

Age-related microvascular dysfunction disrupts nutrient homeostasis and waste clearance, leading to organ failure. However, a critical gap remains in our understanding of the specific molecular drivers of vascular deterioration and how they orchestrate organism-wide aging. Here, we identify progressive activation of th...