Xi-Jun Wang

Influenza virus research in an era of emerging respiratory threats: host–virus interactions, surveillance technologies, antiviral management and resistance, and vaccine preparedness

Seasonal epidemics, zoonotic spillover, antiviral resistance, and pandemic risk continue to make influenza a major challenge for respiratory preparedness. The recent spread of highly pathogenic avian influenza A(H5N1) in mammalian hosts has made it increasingly important to consider molecular adaptation, surveillance,...

Imbalance of the Regulated Cell Death and Autophagic Network: A Core Mechanism Driving Toxicological and Ischemic Myocardial Injury and a Target for Intervention with Traditional Chinese Medicine

Integrated Systems Toxicology Analysis and Molecular Dynamics Study Reveal the Potential Mechanism by which Benzo[a]pyrene Contributes to Depression in Lung Adenocarcinoma via RNASE1 Upregulation

Docking and MD analyses supported stable Bap–RNASE1 binding, involving hydrophobic interactions with key residues and a dominant low-energy conformational state, which provides molecular-level mechanistic insight into the cancer–depression comorbidity driven by environmental carcinogens.

Integrative multi-omics analysis unravels the metabolic landscape and reveals serum biomarkers for early diagnosis of hyperuricemia

The core metabolic and protein regulatory networks of HUA are revealed, and a novel serum metabolite panel for the diagnosis of HUA is identified, providing new insights for improved clinical diagnosis and management.