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Author

Xi-Long Zheng

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Review Oct 2026

Epigenetic regulation of vascular smooth muscle cell plasticity in vascular injury, repair, and aging.

Vascular smooth muscle cells (VSMCs) exhibit a remarkable phenotypic spectrum in response to injury, inflammation, metabolic stress, and aging through state changes encoded in chromatin. This review examines how DNA methylation and hydroxymethylation, histone modifiers, chromatin readers, adenosine triphosphate (ATP)-d...

Xi-Long Zheng, Jia-Xing Sun, Hao Yin et al. · 0 citations
Aug 2026

The cardiac protective human circular RNA circKLHL20_009 sponges miR-31-5p to ameliorate myocardial hypertrophy and fibrosis through suppressing β-catenin signaling.

The expression of the circRNA circKLHL20_009 was significantly upregulated in the myocardium of patients with heart failure and in human cardiomyocytes treated with angiotensin II and an artificial circRNA sponge, circSPmiR31, effectively mitigated cardiac hypertrophy and fibrosis by suppressing miR-31-5p binding to Dk...

Yi-hong Wen, Jia-xue Jiang, W. Dong et al. · 0 citations

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