Molecular basis of metal transport by human ZnT10.
Manganese is essential for immunity and neurological health, and its dysregulation causes Parkinsonism and dystonia. We present cryo-electron microscopy (cryo-EM) structures of human ZnT10, a Mn2+/Zn2+ transporter, in symmetric inward-facing and asymmetric inward/outward states. Conformational shifts in TM1, TM2, TM4,...