Covalently Preorganized (Thio)Urea-Alkoxide Organocatalysts Enable Controlled Synthesis of High-Molecular-Weight Polyglycolide.
Polyglycolide (PGA) is a leading biodegradable polyester, but controlled access to high-molecular-weight PGA remains challenging. Here, we introduce a covalent preorganization strategy that merges H-bond-mediated monomer activation and alkoxide-based chain propagation within a single molecular scaffold. Systematic vari...