Single-cell profiling reveals senescent bone marrow mesenchymal stem cell subpopulations driving pathological ossification in ankylosing spondylitis.
OBJECTIVES Aberrant new bone formation is a hallmark of ankylosing spondylitis (AS), yet the cellular mechanisms remain unclear. Bone marrow-derived mesenchymal stem cells (BMSCs) are crucial for skeletal homeostasis and may be pathologically reprogrammed under chronic inflammation. We aimed to characterize the cellula...