Author

Xi Wang

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Aug 2026

Generation of iPSC-Derived Limbal Epithelial Stem Cells via a Transparent Defined Protocol Optimized by Stromal Cell Co-Culture.

Proprietary differentiation media limit compositional transparency and experimental reproducibility. In this study, we developed a chemically defined limbal differentiation medium (CDLDM) with fully disclosed supplementation for generating induced pluripotent stem cell (iPSC)-derived limbal epithelial stem cell-like ce...

Xi Wang, Xi-Hao Sun, Jia-Ning Gu et al. · Experimental Eye Research · 0 citations

Open access Aug 2026

Nfe2l2-knockout mouse model exhibits oxidative stress-associated stromal degeneration and inflammatory activation resembling keratoconus pathology

Data support a feed-forward axis in which NRF2 deficiency drives oxidative stress, inflammation, and extracellular-matrix degradation that extends to corneal innervation, while NRF2 supplementation partially mitigates these pathological changes.

Xiaoxue Li, Jia-Ning Gu, Xi-Hao Sun et al. · PeerJ · 0 citations