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Open access Sep 2026

AGE-RAGE/NF-κB/SIRT3 signaling cascade is implicated in mitochondrial dysfunction in diabetic gastroparesis

Diabetic gastroparesis is a severe complication of diabetes mellitus, yet its underlying molecular mechanisms remain poorly understood. This study investigated how advanced glycation end products (AGEs) trigger mitochondrial dysfunction through NF-κB activation and SIRT3 suppression in diabetic gastroparesis. We anal...

Peng Zhang, Yao Huang, Ya-Ping Yang et al. · 0 citations
Aug 2026

Shaoyao decoction inhibits neutrophil migration and restores epithelial integrity in ulcerative colitis model mice: insights from single-cell sequencing.

BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory disease that seriously endangers human health. Shaoyao Decoction (SYD) has been widely used in clinical practice to treat UC; however, its active components and molecular mechanisms remain unclear. OBJECTIVE To elucidate the pharmacological mechanisms by wh...

Huantian Cui, Huan Pei, Feitian Min et al. · 0 citations

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