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Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate
TyG-FI, which captures both metabolic dysfunction and physiological frailty, showed stronger associations with advanced CKM syndrome, prevalent CMM, and mortality than most surrogate insulin resistance indices, and may offer a pragmatic tool for early mortality risk stratification in individuals with high cardiometabol...
Faecalibacterium prausnitzii attenuates diabetes-associated affective disorders by suppressing neuroinflammation through the SCFAs/FFAR3/NF-κB/NLRP3 pathway.
BACKGROUND Diabetes-associated affective disorders are a global health burden tightly linked to the gut microbiota. The depletion of Faecalibacterium prausnitzii (F. prausnitzii) is a shared feature of diabetes and depression, yet its therapeutic potential and mechanisms remain unclear. METHODS We first analyzed the...