Engineering of Azo-Crosslinked Alginate Hydrogels for Targeted Oral Local Biologic Delivery
Oral delivery of therapeutic biologics is constrained by gastrointestinal degradation and premature leakage from physical hydrogels. Here, microfluidic-engineered azo-crosslinked alginate (SA-Azo) microspheres were fabricated via template-assisted covalent substitution, yielding uniform matrices with a diameter of 11...