Author

Xian-Feng Hui

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Open access Aug 2026

Lead optimization of 3-indoleacetonitrile identifies candidate compounds with improved anti-influenza activity and safety profiles

Introduction Influenza A virus (IAV) remains a major respiratory pathogen that causes substantial morbidity, mortality, and socioeconomic burden worldwide. Although several antiviral agents are available for clinical use, their effectiveness is often compromised by the emergence of drug-resistant variants, limited ther...

Xian-Feng Hui, Shi-Huan Ding, Bing-Qi Yan et al. · Frontiers in Microbiology · 0 citations

Review Open access Sep 2026

N6-methyladenosine as a potential epitranscriptomic immune rheostat during SARS-CoV-2 infection

N6-methyladenosine (m6A), the most abundant internal RNA modification in eukaryotic cells, has emerged as a critical regulator of antiviral host defense. Increasing evidence indicates that m6A functions beyond conventional post-transcriptional regulation by dynamically coordinating the magnitude, timing, and duration o...

Xian-Feng Hui, Shuo-Xiang Gao, Shi-Huan Ding et al. · Frontiers in Immunology · 0 citations