Author

Xianfeng Xu

2 papers indexed here

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Sep 2026

Characterization of the genomic and transcriptomic landscape of invasive non-mucinous lung adenocarcinoma based on IASLC grading.

BACKGROUND The IASLC grading system has prognostic utility and potential therapeutic implications in invasive non-mucinous lung adenocarcinoma (LUAD), but the molecular basis underlying the grading spectrum remains unclear. METHODS We performed whole-genome sequencing in 138 Chinese patients with invasive non-mucinou...

Lu He, Xian-Feng Xu, Ling-Feng Bi et al. · Lung Cancer · 0 citations

Open access Aug 2026

Large-scale whole-genome sequencing reveals the landscape and health implications of de novo mutations.

Paternal and maternal aging exhibited distinct mutational patterns, with maternal DNM accumulation accelerating at advanced ages, and in vitro embryo manipulation was associated with increased early post-zygotic mosaic mutations, particularly C > A substitutions linked to delayed neurocognitive development at 1 year.

N. Qin, Jun-Cheng Dai, Yue Jiang et al. · Nature Medicine · 1 citation