Xian-G. Sun

Smart nanodelivery systems targeting tumor-associated macrophage reprogramming to potentiate cancer immunotherapy: pharmacological mechanisms, delivery strategies and translational perspectives

Cancer immunotherapy, particularly immune checkpoint blockade, has substantially changed the treatment landscape for multiple malignancies, but clinical benefit remains limited by low response rates, primary tolerance, and acquired resistance. Tumor-associated macrophages (TAMs) are abundant and highly plastic myeloi...