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Xian Gao

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Nov 2026

Sphingolipid Metabolic Dysregulation Drives Cisplatin-Induced Ototoxicity Through Mitochondrial Dysfunction and Intrinsic Apoptosis.

Cisplatin is a widely used chemotherapeutic agent, but its clinical application is limited by irreversible sensorineural hearing loss. Sphingolipid metabolism is increasingly implicated in sensory hair cell (HC) survival, yet its role in cisplatin-induced ototoxicity remains unclear. Here, we investigated the involveme...

Xian Gao, Zi-Xu Zhao, Yi Wang et al. · 0 citations

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