Open access
Jul 2026
A pooled CRISPR-based neuronal activity screen links TMEM50A-dependent MVB function to synaptic integrity and remote memory.
A high-throughput functional genomics platform that couples the calcium-integrating sensor CaMPARI2 with CRISPRi screening in human iPSC-derived neurons is established and reveals a critical role for TMEM50A-dependent MVB function in maintaining synaptic integrity and behavior.
Jian-Hui Wang, Meiqi Liu, Yi-Ming Chen et al.
· Cell Reports · 0 citations