Xian-Ke Xiang

Interpretable machine learning enables de novo mapping of cell type-specific RNA splicing regulation from scRNA-seq data

Context-dependent regulation of alternative splicing, largely mediated by RNA-binding proteins, is a key post-transcriptional mechanism shaping diverse biological processes. Experimental approaches for probing splicing regulation, such as crosslinking-immunoprecipitation assays and RNA-binding protein perturbations, su...