Author

Xian-Ling Cong

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Open access Aug 2026

HMGA1-HP1β axis regulates premature aging in Hutchinson-Gilford progeria syndrome through chromatin remodeling

Hutchinson‑Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by mutations in the LMNA gene. High mobility group A1 (HMGA1) exhibits differential expression patterns across aging models. However, its roles and mechanisms in aging remain unclear. Here, we show a positive correlation between HMGA1...

Qian-Ying Hu, Qian Sun, Wei-Fang Xiang et al. · Nature Communications · 0 citations

Open access Sep 2026

Snail2: roles and regulatory mechanisms in development and disease

Snail2 (SNAI2/Slug), a core C2H2 zinc-finger transcription factor of the Snail superfamily, functions as a master regulator of epithelial-mesenchymal transition (EMT) and cellular plasticity in development and disease. Unlike other EMT transcription factors that drive complete transition, Snail2 distinctively promote...

Yi-Meng Chen, Zheng-Lin He, Yi-Ping Jiao et al. · Cell Death Discovery · 0 citations

Open access Jul 2026

Glycolytic reprogramming and the EMT drive cervical cancer progression via the NQO1/HIF1α-SIX1 axis

It is demonstrated that NQO1 is significantly upregulated in cervical cancer, promoting proliferation, metastasis, and epithelial-mesenchymal transition (EMT) and is a promising therapeutic target.

Guangde Zhu, Zheng-Gen Piao, Yuan Gao et al. · iScience · 1 citation