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Author

Xianlu Lei

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2 papers indexed here

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Nov 2026

Rational design of bispecific aptamers with high stability and affinity.

A robust computational strategy for engineering high-affinity, stable bispecific aptamers for enhanced food safety monitoring by introducing a novel C-type configuration utilizing poly-T linkers with complementary terminal poly-A sequences, facilitating self-assembly via A-T base-pairing.

Shuang Jiang, Yue-Xiang Ren, Xue Wang et al. · 0 citations
Jul 2026

Systematic Scanning Mutagenesis Unveils the Structure-Function Landscape Enabling Aptamer Evolution.

A structure-function landscape for aptamers is introduced, constructed by systematic single-point mutagenesis that maps the contribution of each nucleotide to target binding and highlights its potential to guide the development of high-performance biosensors.

Zhuoer Chen, Qi Sun, Xian-Lu Lei et al. · 0 citations

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