Xian-Miao Ye

Secretory expression of tetrameric neuraminidase enhanced by signal peptide optimization elicits robust immunity against influenza infection in mice.

Neuraminidase (NA), a key surface glycoprotein of influenza viruses, represents a more conserved antigenic target than hemagglutinin (HA) and has attracted interest as a potential target for vaccines with broader protective capacity. Nevertheless, the inefficient secretory production of tetrameric NA that maintain tetr...