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Open access Sep 2026

LIM and SH3 protein 1 deficiency confers resistance to cytotoxic lymphocyte-mediated lysis and immunotherapy in gastric cancer by disrupting cytoskeleton dynamics

Abstract Background A substantial amount of research has been dedicated to the mechanisms by which tumor cells evade immune system recognition and manipulate the immune microenvironment to facilitate immune escape. Recent studies have shown that viruses and tumors can protect themselves from immune cytotoxicity by remo...

Te-Ming Zhang, Ying-Ying Sun, Chao Chen et al. · 0 citations
Open access Sep 2026

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

ABSTRACT Nitric oxide (NO)‐based cancer therapy is fundamentally limited by poor intratumoral penetration of exogenous donors and their inability to sustain localized relevant flux. Here, a multistimuli‐activated Janus nanomotor was developed to interconnect nonenzymatic and enzymatic NO‐generation pathways, enabling i...

Cheng-Cheng Li, Yu Zhang, Yu Chen et al. · 0 citations

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