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Xian-Zhe Zhou

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Review Open access Jul 2026

Clinical advances and multifactorial pathophysiological mechanisms of neuropsychiatric comorbidity in systemic sclerosis

Clinical management of SSc should extend beyond conventional antidepressants and cognitive behavioral therapy to include integrated rheumatology-psychiatry care, IL-6/JAK-targeted biologics and transcutaneous vagus nerve stimulation, all designed to ameliorate patients’ physical and psychiatric symptoms simultaneously.

Jia-Xin Chen, Ronghong Guo, Xian-Zhe Zhou et al. · 0 citations

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