Author

Xiang Chen

3 papers indexed here

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Open access Sep 2026

Mycobacterium tuberculosis Rv0158 negatively regulates the cGAS-STING pathway mediated type I IFN production and enhances intracellular survival.

BACKGROUND Type I interferons (IFN) play an important role in the host defense against Mycobacterium tuberculosis (M. tb) infection and disease pathogenesis. Although M. tb has evolved several mechanisms to evade host immune surveillance, the mechanism used to regulate type I IFN expression remains unclear. METHODS I...

Zheng-Zhong Xu, Min-Li Geng, Zhi-Hong Yao et al. · Journal of microbiology, imm... · 0 citations

Sep 2026

Mycobacterium tuberculosis Rv3248c Inhibits Type I Interferon Response and Promotes Intracellular Survival by Mediating Ubiquitin-Proteasome-Dependent Degradation of TBK1

Mycobacterium tuberculosis (M. tb) is a leading cause of infectious disease mortality worldwide, and M. tb subverts host immunity to persist intracellularly. Type I interferon (IFN-I) modulates host defense during M. tb infection, but the mechanisms controlling their induction remain incompletely defined. In this res...

Zheng-Zhong Xu, Min-Li Geng, Zhi-Fang Zhang et al. · ACS Infectious Diseases · 0 citations

Open access Jul 2026

SH3PXD2B is the critical host factor promoting the entry of mycobacteria

ABSTRACT Bovine tuberculosis (bTB), caused by Mycobacterium bovis, causes major economic losses in the global livestock industry and threatens public health. Macrophages are essential for pathogen clearance, yet serve as the primary intracellular niche for mycobacterial survival. These characteristics emphasize the imp...

Donghui Liu, Ting Zhang, Yu-jie Sheng et al. · Applied and Environmental Mi... · 0 citations