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Review Open access Jul 2026

Coronavirus Nsp15 endoribonuclease: linking viral RNA regulation to immune evasion and viral fitness

ABSTRACT Coronavirus nonstructural protein 15 (Nsp15) is a conserved uridine-preferring endoribonuclease (EndoU). Studies using mouse hepatitis virus (MHV), SARS-CoV-2, and other coronaviruses have shown that Nsp15 associates with replication–transcription complexes (RTCs) and contributes to viral immune evasion. Struc...

Xueying Liang, Xiang Chi, Xufang Deng · 1 citation

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