Lysozyme-Associated Quercetin-Manganese Nanocomposites for Kidney-Targeted Antiferroptotic Therapy of Acute Kidney Injury.
Acute kidney injury (AKI) is a life-threatening syndrome in which oxidative stress, ferroptosis, and inflammatory amplification converge to damage renal proximal tubular epithelial cells. Although antioxidant and antiferroptotic therapies are conceptually attractive, their efficacy is restricted by rapid clearance and...