Gut microbiota, microbial metabolites, and microbiome-directed nutritional interventions in hyperuricemia and gout: mechanisms and translational opportunities.
Hyperuricemia (HUA) and gout are increasingly prevalent metabolic disorders, imposing a substantial global health burden. Although conventional urate-lowering therapies remain the clinical cornerstone, their long-term effectiveness is frequently constrained by adverse effects, variable patient responses, and limited ca...