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Xiang-Ming Zha

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Oct 2026

DLL1 promotes diabetic cataract progression by driving epithelial-mesenchymal transition (EMT) via activation of the Notch signaling pathway.

Diabetic cataracts (DCs) are a major vision-threatening complication of diabetes mellitus; however, their molecular mechanisms remain incompletely understood. The present study aimed to investigate the role of the Notch ligand δ-like ligand 1 (DLL1) in the pathogenesis of DCs. Immunohistochemical analysis revealed elev...

Yuan-Yuan Wang, Ji-Quan Wen, Ting-Ting Zhu et al. · 0 citations
Open access Oct 2026

NE52-QQ57 attenuates post-ischemia protein phosphorylation in the mouse brain

Introduction Cerebral ischemia induces a reduction in brain pH. GPR4, a proton-sensing G protein-coupled receptor is highly expressed in vascular endothelial cells. Pharmacological inhibition of GPR4 with NE52-QQ57 (NEQQ) reduces ischemia-induced blood-brain barrier (BBB) disruption and brain injury. To facilitate targ...

Shambhu Joshi, You-Fang Zhou, Xiang-Ming Zha · 0 citations

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