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Xiang-Qian Zhang

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Open access Sep 2026

Fungal extracellular vesicles reshape Lactobacillus rhamnosus vesicles to enhance lysosomal homeostasis and resolve intestinal inflammation

Abstract Extracellular vesicles (EVs) are emerging mediators of intercellular and interkingdom communication. While bacterial EVs directly modulate host health, whether exogenous vesicles can reprogram gut microbial vesiculation and bioactivity remains unclear. Using a defined in vitro conditioning system, ScEV exposur...

Zheng-Mei Ji, Guo-Liang Chen, Xiao-Long He et al. · 0 citations
Open access Aug 2026

Calycosin targets the MAPK-EGR1 signaling axis to inhibit enterovirus 71 replication in cells and human colonic organoids

It is shown that early growth response 1 (EGR1) is independently regulated by each of the three classical MAPK branches including extracellular signal-regulated kinase (ERK), p38 and c-Jun N-terminal kinase (JNK), and serves as a common downstream target of these pathways to promote EV71 replication and virus-induced c...

Yue Liu, Jiale Wang, Xin Chen et al. · 0 citations

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