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Xiang-Shu Xiao

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Open access Sep 2026

Protein Age Bias in Target Degradation by PROTACs.

Targeted protein degradation (TPD) by PROteolysis TArgeting Chimeras (PROTACs) has emerged as a powerful chemical biology and therapeutic modality, yet many degraders exhibit incomplete target clearance and characteristic rebound kinetics despite continuous exposure. The mechanistic basis for this behavior remains poor...

Bing-Bing X. Li, Xiang-Shu Xiao · 0 citations

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