Review
Open access
Aug 2026
Piezo1-mediated Mechanotransduction in the musculoskeletal system: Signaling networks and therapeutic perspectives
Mechanical forces are integral to musculoskeletal homeostasis and pathology. Piezo1 is a mechanosensitive ion channel widely expressed in bone, cartilage, muscle, and tendon. It converts mechanical stimuli (tension, compression, shear) into Ca2+ influx and downstream signals, regulating proliferation, differentiation,...
Hong Zhao, Jun-Yang Huang, Ya-Yi Tan et al.
· Bone Reports · 0 citations