Author

Xiang-Yang Xue

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Open access Oct 2026

Repurposing ritonavir to induce proteasomal degradation of IE1 for inhibition of human cytomegalovirus replication.

Human cytomegalovirus (HCMV) is a major pathogen affecting immunocompromised individuals. Current antiviral drugs target the mid-to-late stages of viral replication but are limited by toxicity and drug resistance. The IE1 protein serves as a key early regulator of HCMV replication; however, it has long been considered...

Wan-Feng Liu, Yu Shi, Xu-Dong Guo et al. · PLoS Computational Biology · 0 citations

Aug 2026

FAM117B Promotes Malignant Progression of Hepatocellular Carcinoma by Forming a Bidirectional Regulatory Loop with NAT10 and Activating the JAK-STAT3 Pathway.

The molecular mechanism by which FAM117B promotes HCC progression via forming a bidirectional regulatory loop with NAT10 and activating the JAK-STAT3 signaling pathway through acetylation modification is revealed, providing a novel potential target and theoretical basis for targeted therapy of HCC.

Zhao-Hong Wang, Jian-Feng Fang, Lijun Wu et al. · Experimental Cell Research · 0 citations