Author

Xiang Ye

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Open access Aug 2026

PKR engages viral RNA and intron-retained host transcripts during poxvirus infection.

Recognition of double-stranded (ds) RNA is central to antiviral defense, yet how RNA sensors are activated during infection remains unclear. Here, we demonstrate that during vaccinia virus (VacV) infection, PKR binding is enriched on viral RNAs and host-intron-containing transcripts. During infection, RNase L activatio...

Rui-Lin Zhang, Xiang Ye, Andrew C. Dixson et al. · Cell Reports · 0 citations

Open access Sep 2026

RNA binding proteome profiling reveals RNA-dependent activation of oncogenic host signaling during KSHV infection

Viruses encode RNA-binding proteins (RBPs) to manipulate host processes and promote infection. However, due to limited genomic space, many viral proteins are multifunctional and may engage RNA through non-canonical domains, making their identification difficult using traditional sequence-based approaches. Kaposi’s sa...

Yang Zhao, Xiang Ye, Madeline Yuen et al. · Nature Communications · 0 citations