Background
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI). Inspired by the synergistic hepatoprotective effects of (20S, 24R)-ocotillol (OC) and lipoic acid (LA), we designed and synthesized OCLA, a novel ginsenoside derivative that has been granted a patent.
Methods
The structur...
Han Liu, Qiu-Yue Zhang, Wei Shang et al.· Frontiers in Pharmacology· 0 citations
Flow cytometry enables the simultaneous characterization of multiple immune-cell populations and their phenotypic subsets in clinical specimens. However, comprehensive immunophenotyping of limited blood and tumor samples can be challenging because of limited cell availability, sample-processing requirements, and the ne...
Hao-Jie Wang, Cai-Ru Guo, Yu-Jie Niu et al.· Journal of Visualized Experi...· 0 citations
This review systematically elucidates the multidimensional molecular regulatory networks through which senescent tumor cells promote tumor recurrence, encompassing key processes such as cell cycle reactivation mechanisms, epithelial-mesenchymal transition (EMT), acquisition of stemness phenotypes, formation of polyploi...
