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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Xiangwei Xu

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Open access Jul 2026

Discovery of novel METTL3 inhibitors: design, synthesis, and in silico and in vitro evaluations

Methyltransferase-like protein 3 (METTL3) is a promising therapeutic target for Acute Myeloid Leukemia (AML). To discover novel METTL3 inhibitors, we designed a series of compounds by hybridizing the natural product Genistein and the non-nucleoside METTL3 inhibitor STM2457. Among the 31 de novo-generated compounds subj...

Yun Zhang, Meng-Yan Chen, Yanwen He et al. · 0 citations

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