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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Xiangyu Zhang

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Jul 2026

AI-Driven Discovery of a Hydrophobic-Tag Degrader Targeting NSD3 for Lung Squamous Carcinoma Therapy.

Nuclear receptor-binding SET domain protein 3 (NSD3) is a histone H3K36 methyltransferase implicated in lung squamous cell carcinoma, yet chemical targeting is challenging due to the shallow PWWP reader pocket. Here, we report XSY12, a hydrophobic-tag degrader of the NSD3 PWWP domain that enables cellular NSD3 depletio...

Si-Yu Xiu, Zhenyu Jia, Qi Li et al. · 0 citations

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