Author

Xiangzhuan Zhao

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Open access Aug 2026

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

It is demonstrated that the m5C methyltransferase NSUN6 is significantly upregulated in EC tissues, and its expression correlates with higher tumor grade and unfavorable prognosis, and a proof‐of‐concept inhibitor, AL398, is provided, laying the groundwork for the development of first‐in‐class RNA methylation‐targeted...

Xiangzhuan Zhao, Lin-Lin Yang, Huanxiang Chen et al. · Advancement of science · 0 citations

Open access Aug 2026

TRDMT1 Slows Lung Cancer Growth by Stabilizing TFRC mRNA and Triggering Ferroptosis Cell Death.

A novel TRDMT1-TFRC regulatory axis that suppresses LUAD progression through the modulation of ferroptosis is unveiled, highlighting this pathway as a promising therapeutic target for future interventions.

Ying Zhu, Zuli Jiang, Youming Chen et al. · Journal of Biological Chemis... · 0 citations