Dietary Citrus Flavonoid Hesperetin Attenuates Metabolic Dysfunction-Associated Steatotic Liver Disease via Modulation of MAPK-RARα Axis.
Metabolic dysfunction-associated steatotic liver disease (MASLD) lacks effective nutrition-based interventions. Hesperetin, a dietary citrus flavonoid, was evaluated for its hepatoprotective mechanism using high-fat diet-induced MASLD mice and free fatty acid-challenged hepatocytes. Hesperetin improved glucose and lipi...