Reduced astrocytic Homer1a expression mediates mPFC excitatory synaptic dysfunction and neurodevelopmental deficits after maternal immune activation
Prenatal maternal immune activation (MIA) during pregnancy is a prominent environmental contributor to neurodevelopmental disorders and psychiatric conditions in offspring, but the precise brain-region- and cell-type-specific mechanisms remain unclear. Using a lipopolysaccharide (LPS)-induced MIA mouse model, we show...