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Xiao-Chuan Wu

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Open access Aug 2026

Distinct peripheral B-cell immunophenotypes define clinical heterogeneity in childhood-onset systemic lupus erythematosus

B-cell dysregulation is central to the pathogenesis of childhood-onset systemic lupus erythematosus (cSLE), yet the B-cell immunophenotypes across disease states remain incompletely defined. This study aimed to investigate the mechanistic basis and clinical relevance of B-cell–mediated immune dysregulation in cSLE. Per...

Li-Yun Xu, Hui Chen, Yong-Zhen Li et al. · 0 citations
Jul 2026

A Multi-Center Integrative Cohort Characterizing the Genetic, Clinical, and Transcriptomic Features of ACP5 Deficiency.

An upregulated interferon signature was revealed, and monocytes were identified as a major cellular source of inflammation in patients with SPENCDI, expanding the genetic and clinical spectrum of ACP5 deficiency.

Shiling Zhong, Shuang-Yue Ma, Y. El Chazli et al. · 0 citations

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