Aug 2026
Osteoclast-lineage Indian hedgehog sustains RANKL-induced osteoclastogenesis and bone resorption via the JNK/c-Fos/NFATc1 axis during postnatal bone remodeling.
PURPOSE Bone remodeling depends on the coordinated balance between osteoclast-mediated resorption and osteoblast-mediated formation. Although Indian hedgehog (Ihh) is known to regulate skeletal development and bone homeostasis, its direct involvement in osteoclastogenesis remains unclear. METHODS We generated a novel...
Jian Sun, Si-Qian Liu, Xinle Che et al.
· Connective Tissue Research · 0 citations