Xiao-Dan Long

Immune cell fibrotic plasticity: mesenchymal-like reprogramming of macrophages, neutrophils and T cells

Fibrosis has traditionally been viewed as a fibroblast- and myofibroblast-centred process, in which immune cells regulate matrix deposition primarily through inflammatory mediators and paracrine signalling. However, advances in single-cell profiling, spatial analyses and lineage-resolved approaches are beginning to cha...