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Xiao-Fang Gao

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Open access Sep 2026

Pharmacological activation of SIRT1 alleviates sepsis-associated acute kidney injury by improving renal mitochondrial energy metabolism

Abstract Sepsis-associated acute kidney injury (SA-AKI) is a frequent and severe complication of sepsis and is closely associated with increased mortality. Mitochondrial dysfunction and impaired energy metabolism are important contributors to SA-AKI pathogenesis. Silent information regulator 1 (SIRT1), a nicotinamide a...

Rui Zhu, Hai-Rong Yang, Li Liu et al. · 0 citations

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