Akkermansia muciniphila alleviates osteoporosis by suppressing bone marrow adiposity through the gut microbiota-UDCA-TGR5 axis.
Osteoporosis (OP) is characterized not only by progressive bone loss but also frequently by pathological bone marrow adiposity (BMA) expansion. Akkermansia muciniphila (AKK), implicated in lipid metabolic homeostasis, was previously found to be markedly depleted during estrogen deficiency-associated bone loss. However,...