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Xiaofang Jiang

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Open access Aug 2026

Ancestral proteins trace the emergence of substrate specificity and oligomerization within bacterial DEDDy dinucleases

Nucleases are crucial for various bacterial processes, including genome maintenance and host defense. Deoxydinucleases (diDNases), a class of Gram-positive bacteria–specific nucleases associated with mobile genetic elements, are homologous to nanoRNase C (NrnC) in Gram-negative bacteria but exhibit notable differences:...

Sofia Mortensen, Audrey A. Burnim, K. Dufault-Thompson et al. · Science Advances · 0 citations

Open access Sep 2026

LAMBDA: a prophage detection benchmark for genomic language models.

Transformer-based genomic sequence models represent an emerging frontier in computational biology. Yet, their embeddings have not yet shown the same level of predictive power as natural and protein language models, highlighting a gap between current implementations and theoretical promise. Existing benchmarks for DNA l...

LeAnn M. Lindsey, Nicole L. Pershing, K. Dufault-Thompson et al. · NAR Genomics and Bioinformat... · 0 citations

Open access Aug 2026

Structure of a key adhesin-exopolysaccharide interaction provides insights into matrix assembly in Vibrio cholerae biofilms

The structure reveals for the first time the interaction between a biofilm exopolysaccharide and matrix protein, as well as insights into conformational changes of exopolysaccharide induced by this binding, and provides a generalizable approach for studying the biophysical and biochemical properties of carbohydrate-dep...

Alex Hinbest, Hyerim Bianca Nam, E. Liszczyk et al. · bioRxiv · 0 citations