Author

Xiaofang Tang

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Open access Oct 2026

The COL4A3 c.3418+1G>T variant causes exon 39 skipping in minigene assays: functional and exploratory structural analyses

Background Canonical splice-site variants are an important cause of Alport syndrome, but the transcript consequences of many heterozygous COL4A3 variants remain experimentally unverified. We characterized COL4A3 c.3418 + 1G>T in a 38-year-old woman with persistent isolated microscopic hematuria. Notably, the proband’s...

Xuan Ban, Yue Wang, Yun-Shan Guo et al. · Frontiers in Genetics · 0 citations

Open access Aug 2026

Sodium Butyrate Attenuates Renal Fibrosis by Regulating Glycolysis and Histone H4K12 Lactylation in Diabetic Kidney Disease

This study investigated the contribution of histone H4 lysine 12 lactylation to abnormal glycolysis and renal fibrogenesis in diabetic kidney disease (DKD) and evaluated sodium butyrate (NaB) as a potential therapeutic modulator.

Ping He, Ming-Xiu Wang, Hang Mei et al. · Diabetes, obesity and metabo... · 0 citations