Author

Xiao-Fei Zheng

3 papers indexed here

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Oct 2026

MIF-CD74 orchestrates synovial macrophage metabolic-inflammatory reprogramming by ENO2 interaction to drive osteoarthritis pathogenesis.

Synovitis is a central driver of osteoarthritis (OA) progression, yet the cellular and molecular mechanisms sustaining inflammatory circuits in the synovium remain incompletely understood. Through integrative analysis of time-resolved single-cell RNA sequencing in murine synovium and spatial transcriptomics of human OA...

Rui Peng, Bo Yu, Yu-Long Wei et al. · Science Translational Medici... · 0 citations

Open access Oct 2026

MAMDC2 drives microglia-mediated neuroinflammation via CAND1-dependent IκBα ubiquitination and is targetable by Artemvulactone E.

Sustained microglial activation is a common feature of many neurological disorders, yet the upstream molecular amplifiers that sustain this process remain poorly defined. Our earlier work identified MAM domain-containing 2 (MAMDC2) as an immune regulator enriched in microglia with an established role in antiviral immun...

Tao Liu, Feng Gao, Yi-Liang Wang et al. · Pharmacological Research · 0 citations

Open access Sep 2026

A novel classification system for avulsion fractures of the distal fibula based on arthroscopy-assisted measurement and significance to surgery and rehabilitation.

Background There are difficulties in clinically diagnosing avulsion fractures of the distal fibula, although arthroscopic examination is an effective diagnostic method. To propose a novel classification scheme for avulsion fractures of the distal fibula, and further provide guidance for surgical and rehabilitation stra...

Lin-Guo He, Q. Teng, Wen-Rui Wu et al. · Frontiers in Medicine · 0 citations