A porcine acellular nerve matrix membrane with dual neurotrophic and immunomodulatory functions accelerates peripheral nerve regeneration by coordinating Schwann cell activation and remyelination.
Repairing peripheral nerve injuries remains challenging because it requires biomaterials that can simultaneously modulate the adverse immune microenvironment and provide a bionic niche with integrated physical and biochemical cues. To address this, we developed a porcine sciatic nerve-derived acellular matrix membrane...