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Xiaogang Li

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Open access Aug 2026

Targeting Runx1 Slows Cyst Growth in Autosomal Dominant Polycystic Kidney Disease

Mechanistically, Runx1 enhances proliferation of cyst‐lining epithelial cells by activating the AKT–mTOR, MAPK, and STAT3 signaling cascades, while suppressing p53‐mediated apoptosis.

Yue-Yue Zhang, Chang Liu, Jun-Chi Liu et al. · 0 citations
Open access Jul 2026

A cross-model single-cell atlas reveals conserved involvement of osteopontin in polycystic kidney disease

An integrated single-cell RNA sequencing atlas across mouse models of PKD is constructed, mapping changes in cell type composition, gene expression, and intercellular signaling networks across the whole atlas and within individual models.

S. Miller, Hua Zhong, Weidong Wu et al. · 0 citations

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